Research Paper Volume 13, Issue 12 pp 15917—15941

Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization

PDS alters the structure of chromatin and cytoplasm in primary neurons, astrocytes, and microglia. Representative electron micrographs of cultured cortical neurons, astrocytes, and microglia treated with a vehicle overnight (left panel) and with 2 μM PDS overnight (right panel). Bar (neuronal cells), 1 μm; bar (astrocytes and microglia), 2 μm. Primary cultures were fixed and processed for electron microscopy imaging. Results were pooled from two independent experiments.

Figure 2. PDS alters the structure of chromatin and cytoplasm in primary neurons, astrocytes, and microglia. Representative electron micrographs of cultured cortical neurons, astrocytes, and microglia treated with a vehicle overnight (left panel) and with 2 μM PDS overnight (right panel). Bar (neuronal cells), 1 μm; bar (astrocytes and microglia), 2 μm. Primary cultures were fixed and processed for electron microscopy imaging. Results were pooled from two independent experiments.