Research Paper Volume 13, Issue 14 pp 18223—18237

Combination of rapamycin and SAHA enhanced radiosensitization by inducing autophagy and acetylation in NSCLC

Effects of combination treatment with RAPA and SAHA on A549 xenografts model after receiving IR. (A) Bodyweight in A549 cell xenografts measured every 4 days. (B, C) Specimens and tumor weight of A549 cell xenograft after different treatments for 28 days. (D) Tumor volume of A549 cell xenograft in nude mice measured every 4 days. (E) Immunohistochemical staining of γ-H2AX, LC3 and Ac-H3 in A549 cell xenografts (×200).

Figure 6. Effects of combination treatment with RAPA and SAHA on A549 xenografts model after receiving IR. (A) Bodyweight in A549 cell xenografts measured every 4 days. (B, C) Specimens and tumor weight of A549 cell xenograft after different treatments for 28 days. (D) Tumor volume of A549 cell xenograft in nude mice measured every 4 days. (E) Immunohistochemical staining of γ-H2AX, LC3 and Ac-H3 in A549 cell xenografts (×200).