Research Paper Volume 13, Issue 13 pp 17370—17379

Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling

PPI network of baicalein-targeted genes. (A) PPI network of baicalein-targeted genes constructed using Cytoscape. (B) A list of baicalein-targeted genes in the PPI network ranked by degree connectivity. As shown, the top ten baicalein-targeted genes by degree connectivity were AKT1, CCND1, PTEN, MTOR, CDK4, CDKN1A, CDKN1B, CDKN2A, FOXO3, and FOXO1.

Figure 2. PPI network of baicalein-targeted genes. (A) PPI network of baicalein-targeted genes constructed using Cytoscape. (B) A list of baicalein-targeted genes in the PPI network ranked by degree connectivity. As shown, the top ten baicalein-targeted genes by degree connectivity were AKT1, CCND1, PTEN, MTOR, CDK4, CDKN1A, CDKN1B, CDKN2A, FOXO3, and FOXO1.