Research Paper Volume 13, Issue 13 pp 17473—17488

Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

ALK4 haplodeficiency attenuates the activation of the Smad2/3 pathway and promotes activation of the AMPK pathway in macrophages. (A, B) Smad2/3 phosphorylation expression in macrophages deriving from the bone marrows of WT and ALK4+/- mice in 4 groups (n=4 for each). (C, D) AMPK expression in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). (E, F) ATK expression in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). * p

Figure 7. ALK4 haplodeficiency attenuates the activation of the Smad2/3 pathway and promotes activation of the AMPK pathway in macrophages. (A, B) Smad2/3 phosphorylation expression in macrophages deriving from the bone marrows of WT and ALK4+/- mice in 4 groups (n=4 for each). (C, D) AMPK expression in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). (E, F) ATK expression in bone marrow derived macrophages from WT and ALK4+/- mice stimulated by IL-4 in 4 groups (n=4 for each). * p<0.05.