Research Paper Volume 13, Issue 13 pp 17536—17547

IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats

Effects of cardiac specific IGFIIRα overexpressing DM rats on interstitial collagen. Masson’s trichrome staining (n=3) show difference in collagen accumulation in Non-transgenic rats (NTG), transgenic (TG), NTG-streptozotocin induced diabetes model (NTGSTZ), TG streptozotocin induced diabetes model (TGSTZ). NTGSTZ induced DM rats show collagen accumulation (blue stain). TG rats show elevated interstitial collagen accumulation compared to NTG and NTGSTZ rats. Scale bar represent 100 μm at 40 x magnification.

Figure 5. Effects of cardiac specific IGFIIRα overexpressing DM rats on interstitial collagen. Masson’s trichrome staining (n=3) show difference in collagen accumulation in Non-transgenic rats (NTG), transgenic (TG), NTG-streptozotocin induced diabetes model (NTGSTZ), TG streptozotocin induced diabetes model (TGSTZ). NTGSTZ induced DM rats show collagen accumulation (blue stain). TG rats show elevated interstitial collagen accumulation compared to NTG and NTGSTZ rats. Scale bar represent 100 μm at 40 x magnification.