Research Paper Volume 13, Issue 13 pp 17673—17689

Circular RNA circCCDC66 promotes glioma proliferation by acting as a ceRNA for miR-320a to regulate FOXM1 expression

Enhanced circCCDC66 in promoted glioma cell proliferation. (A) Relative expression of circCCDC66 in glioma tissue samples and their paired non-cancerous tissue samples measured by RT-qPCR. (B) Relative expression of circCCDC66 in glioma cell lines and normal cell line measured by qRT-PCR. (C, D) Relative circCCDC66 expression in SW1783 and U373 cells after transfection. (E, F) Cell viability was decreased in SW1783 and U373 cells transfected with si-circCCDC66. *P P P

Figure 1. Enhanced circCCDC66 in promoted glioma cell proliferation. (A) Relative expression of circCCDC66 in glioma tissue samples and their paired non-cancerous tissue samples measured by RT-qPCR. (B) Relative expression of circCCDC66 in glioma cell lines and normal cell line measured by qRT-PCR. (C, D) Relative circCCDC66 expression in SW1783 and U373 cells after transfection. (E, F) Cell viability was decreased in SW1783 and U373 cells transfected with si-circCCDC66. *P < 0.05, **P < 0.01, ***P < 0.001.