Research Paper Volume 13, Issue 15 pp 19293—19305

Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells

Apremilast protects ESCs against IL-1α-induced impairment in capacities of ESCs. Cells were stimulated with 5 ng/mL IL-1α in the presence or absence of 1.5 or 3 μM Apremilast for 12 hours. (A) mRNA of integrin β1; (B). mRNA of Krt19; (C). Protein levels of integrin β1 and Krt19 (**, ****, P #, ##, P N = 5).

Figure 9. Apremilast protects ESCs against IL-1α-induced impairment in capacities of ESCs. Cells were stimulated with 5 ng/mL IL-1α in the presence or absence of 1.5 or 3 μM Apremilast for 12 hours. (A) mRNA of integrin β1; (B). mRNA of Krt19; (C). Protein levels of integrin β1 and Krt19 (**, ****, P < 0.01, 0.0005 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. IL-1α treatment group, N = 5).