Research Paper Volume 13, Issue 13 pp 17734—17767

Clinical significance and prognostic role of an immune-related gene signature in gastric adenocarcinoma

Validation of the prognostic performance of the immune-related gene signature in an independent group based on 145 frozen tissues. (A) Distribution of the risk score, survival status, and gene expression panel. (B) Kaplan-Meier curves of OS in all GAC patients based on the risk score. (C) ROC curve analysis of the immune-related gene signature for the prediction of OS at 2, 3, and 4 years in the independent cohort. (D) ROC curve analysis for the prediction of OS at 3 years in an independent cohort based on multiple clinical features. (E) ROC curve analysis for the prediction of OS at 4 years in an independent cohort based on multiple clinical features. (G) The expression of 9 immune genes in gastric cancer tissues and their corresponding normal tissues. (F) We also compared the differential expression of 9 immune genes between the high- and low-risk groups.

Figure 5. Validation of the prognostic performance of the immune-related gene signature in an independent group based on 145 frozen tissues. (A) Distribution of the risk score, survival status, and gene expression panel. (B) Kaplan-Meier curves of OS in all GAC patients based on the risk score. (C) ROC curve analysis of the immune-related gene signature for the prediction of OS at 2, 3, and 4 years in the independent cohort. (D) ROC curve analysis for the prediction of OS at 3 years in an independent cohort based on multiple clinical features. (E) ROC curve analysis for the prediction of OS at 4 years in an independent cohort based on multiple clinical features. (G) The expression of 9 immune genes in gastric cancer tissues and their corresponding normal tissues. (F) We also compared the differential expression of 9 immune genes between the high- and low-risk groups.