Research Paper Volume 13, Issue 13 pp 17768—17788

Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma

Mutated-types, co-mutations and the mutation location of CDH23 in DLBCL. (A) Aberration types and frequency of CDH23 in DLBCL. (B) Volcano plots of mutations in CDH23 altered group and unaltered group. Blue dots denote genes mutated significantly (pC) Aberration frequency scatter in CDH23 altered group and unaltered group. Blue dots denote genes mutated significantly (pD) Co-mutations with CDH23 in DLBCL. (E) Locations of CDH23 mutations in DLBCL. CNA: DNA copy-number alteration.

Figure 2. Mutated-types, co-mutations and the mutation location of CDH23 in DLBCL. (A) Aberration types and frequency of CDH23 in DLBCL. (B) Volcano plots of mutations in CDH23 altered group and unaltered group. Blue dots denote genes mutated significantly (p<0.05), and grey dots denote genes don’t mutate significantly (p≥0.05). (C) Aberration frequency scatter in CDH23 altered group and unaltered group. Blue dots denote genes mutated significantly (p<0.05), and grey dots denote genes don’t mutate significantly (p≥0.05). (D) Co-mutations with CDH23 in DLBCL. (E) Locations of CDH23 mutations in DLBCL. CNA: DNA copy-number alteration.