Research Paper Volume 13, Issue 14 pp 18340—18359

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression

MiR-431-5p reverses the tumor-suppressive effects of circSPIDR in CADC cells. (A) CCK-8 assay evaluating the viability of HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. (B) Colony formation assay in HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. (C) Apoptosis analysis of HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. NS, not significant; *P **P ***P

Figure 5. MiR-431-5p reverses the tumor-suppressive effects of circSPIDR in CADC cells. (A) CCK-8 assay evaluating the viability of HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. (B) Colony formation assay in HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. (C) Apoptosis analysis of HeLa cells co-transfected with circSPIDR and miR-431-5p mimics. NS, not significant; *P < 0.05; **P < 0.01; ***P < 0.001.