Research Paper Volume 13, Issue 14 pp 18340—18359

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression

The clinical value of circSPIDR, miR-431-5p, SORCS1 and CUBN expression in CADC tissues. (A) Violin plots showing circSPIDR, miR-431-5p, SORCS1 and CUBN levels determined using qRT-PCR in 57 normal cervical tissues and 141 CADC tissues. (B–D) Pearson correlation analysis between circSPIDR levels and miR-431-5p (B), SORCS1 (C), CUBN (D) levels. (E, F) Pearson correlation analysis between miR-431-5p levels and SORCS1 (E) or CUBN (F) levels. (G) ROC curve analysis of circSPIDR, miR-431-5p, SORCS1 and CUBN detection for CADC diagnosis. ***P

Figure 8. The clinical value of circSPIDR, miR-431-5p, SORCS1 and CUBN expression in CADC tissues. (A) Violin plots showing circSPIDR, miR-431-5p, SORCS1 and CUBN levels determined using qRT-PCR in 57 normal cervical tissues and 141 CADC tissues. (BD) Pearson correlation analysis between circSPIDR levels and miR-431-5p (B), SORCS1 (C), CUBN (D) levels. (E, F) Pearson correlation analysis between miR-431-5p levels and SORCS1 (E) or CUBN (F) levels. (G) ROC curve analysis of circSPIDR, miR-431-5p, SORCS1 and CUBN detection for CADC diagnosis. ***P < 0.001.