Research Paper Volume 13, Issue 14 pp 18527—18544

LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis

LncRNA CCAT1 was up-regulated in PCa tissues and cell lines. (A) Scatter diagram of CCAT1 expression in PCa tissues and adjacent tissues of 10 clinical samples. CCAT1 expression was generally higher in PCa tissues compared with adjacent normal tissues. (B) CCAT1 expression in human normal prostate epithelial cell line and four human PCa cell lines (LnCaP, DU145, PC3, and 22RV1). CCAT1 expression level was remarkably increased in PCa cell lines compared with the RWPE-1 cell line. (C) lncLocator (<a href="http://www.csbio.sjtu.edu.cn/bioinf/lncLocator/" target="

Figure 1. LncRNA CCAT1 was up-regulated in PCa tissues and cell lines. (A) Scatter diagram of CCAT1 expression in PCa tissues and adjacent tissues of 10 clinical samples. CCAT1 expression was generally higher in PCa tissues compared with adjacent normal tissues. (B) CCAT1 expression in human normal prostate epithelial cell line and four human PCa cell lines (LnCaP, DU145, PC3, and 22RV1). CCAT1 expression level was remarkably increased in PCa cell lines compared with the RWPE-1 cell line. (C) lncLocator (http://www.csbio.sjtu.edu.cn/bioinf/lncLocator/) prediction results of CCAT1. CCAT1 was predicted to mainly exist in the cytosol. (D) Subcellular location analysis of CCAT1 in LnCaP and PC3 cells. CCAT1 was distributed in the cytoplasm of LnCaP and PC3 cells. **P < 0.01, compared with the normal tissues or cells.