Research Paper Volume 13, Issue 14 pp 18527—18544

LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis

Knockdown of CCAT1 up-regulated the expression of E-cadherin, while down-regulated the expression of N-cadherin and Vimentin. (A) The protein levels of E-cadherin, N-cadherin, and Vimentin in LnCaP and PC3 cells after si-CCAT1 transfection. (B) The protein levels of E-cadherin, N-cadherin, and Vimentin in LnCaP and PC3 cells after pcDNA-CCAT1 transfection. *P P

Figure 3. Knockdown of CCAT1 up-regulated the expression of E-cadherin, while down-regulated the expression of N-cadherin and Vimentin. (A) The protein levels of E-cadherin, N-cadherin, and Vimentin in LnCaP and PC3 cells after si-CCAT1 transfection. (B) The protein levels of E-cadherin, N-cadherin, and Vimentin in LnCaP and PC3 cells after pcDNA-CCAT1 transfection. *P < 0.05, **P < 0.01, compared with the si-NC group or the empty vector group.