Research Paper Volume 13, Issue 14 pp 18606—18619

Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats

AMPK activation attenuates neuropathic pain enhancement in obese rats. (A) The protocol of Part 2. (B) Allodynia in the OCCD+saline and OCCD+metformin groups was detected by the PWMT test at the indicated time points after CCD surgery.. N = 10-15 per group, *P **P

Figure 2. AMPK activation attenuates neuropathic pain enhancement in obese rats. (A) The protocol of Part 2. (B) Allodynia in the OCCD+saline and OCCD+metformin groups was detected by the PWMT test at the indicated time points after CCD surgery.. N = 10-15 per group, *P < 0.05 vs. OCCD+saline group, **P < 0.01 vs. OCCD+saline group. OCCD, obese CCD; PWMT, paw withdrawal mechanical threshold.