Research Paper Volume 13, Issue 14 pp 18689—18700

Catalpol enhanced physical exercise-mediated brain functional improvement in post-traumatic stress disorder model via promoting adult hippocampal neurogenesis

Catalpol promoted the neurogenic improvement effects of the treadmill by accelerating neural differentiation. (A) MCM2 staining (green) in DG to assess the NSCs proliferation. DAPI was used for unclear labelling. (B) No significant difference showed among groups for MCM2 positive cell density. (C) DCX staining (green) in DG to assess the NSCs neural differentiation. DAPI was used for unclear labelling. (D) Statistical analysis of the DCX positive cell density in different groups. One-way ANOVA, ***p #p ##p ###p

Figure 4. Catalpol promoted the neurogenic improvement effects of the treadmill by accelerating neural differentiation. (A) MCM2 staining (green) in DG to assess the NSCs proliferation. DAPI was used for unclear labelling. (B) No significant difference showed among groups for MCM2 positive cell density. (C) DCX staining (green) in DG to assess the NSCs neural differentiation. DAPI was used for unclear labelling. (D) Statistical analysis of the DCX positive cell density in different groups. One-way ANOVA, ***p < 0.001 vs. control; #p < 0.05, ##p < 0.01, ###p < 0.001.