Research Paper Volume 13, Issue 14 pp 18689—18700

Catalpol enhanced physical exercise-mediated brain functional improvement in post-traumatic stress disorder model via promoting adult hippocampal neurogenesis

Adult neurogenesis is required for catalpol to promote exercise therapeutic effects to panic memory retrieve and antidepressant. (A) Experimental procedure to block the adult hippocampal neurogenesis with TMZ injection. (B) Daily freezing time response change among different treatments. (C) Statistical analysis of the mobility time in FST among different treatments. (D) Statistical analysis of the staying time at center region in OFT among different treatments. (E) Statistical analysis of the swimming time at target zone in probe trail among different treatments. One-way ANOVA, *p ***p ****p

Figure 6. Adult neurogenesis is required for catalpol to promote exercise therapeutic effects to panic memory retrieve and antidepressant. (A) Experimental procedure to block the adult hippocampal neurogenesis with TMZ injection. (B) Daily freezing time response change among different treatments. (C) Statistical analysis of the mobility time in FST among different treatments. (D) Statistical analysis of the staying time at center region in OFT among different treatments. (E) Statistical analysis of the swimming time at target zone in probe trail among different treatments. One-way ANOVA, *p < 0.05, ***p < 0.001, ****p < 0.0001.