Research Paper Volume 13, Issue 17 pp 21102—21121

Bortezomib enhances the anti-cancer effect of the novel Bruton’s tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK

Cell apoptosis in the MCL cell lines after being treated with BGB-3111. The cell apoptosis of Jeko-1 (A) Rec-1 (B) and Z138 (C) treated with BGB-3111 at the doses of 0 μM, 3 μM, 6 μM, and 9 μM for 48 h. The cell apoptotic rate was detected by flow cytometry.

Figure 4. Cell apoptosis in the MCL cell lines after being treated with BGB-3111. The cell apoptosis of Jeko-1 (A) Rec-1 (B) and Z138 (C) treated with BGB-3111 at the doses of 0 μM, 3 μM, 6 μM, and 9 μM for 48 h. The cell apoptotic rate was detected by flow cytometry.