Research Paper Advance Articles

Endothelial microparticle-associated protein disulfide isomerase increases platelet activation in diabetic coronary heart disease

Comparison of platelet activation and platelet-leukocyte aggregate levels in the diabetic CHD group and non-diabetic CHD group. (A) Detection of CD62p expression level on platelet surface by flow cytometry of diabetic CHD group and non-diabetic CHD group. (B) Detection of PAC-1 expression level on platelet surface by flow cytometry of diabetic CHD group and non-diabetic CHD group. (C) Detection of platelet-leukocyte (CD45+ CD41a+) adhesion by flow cytometry of diabetic CHD group (n=121) and non-diabetic CHD group (n=102). Values are expressed as mean±SD. Analyses were done by t-test for independent samples. *PPP

Figure 1. Comparison of platelet activation and platelet-leukocyte aggregate levels in the diabetic CHD group and non-diabetic CHD group. (A) Detection of CD62p expression level on platelet surface by flow cytometry of diabetic CHD group and non-diabetic CHD group. (B) Detection of PAC-1 expression level on platelet surface by flow cytometry of diabetic CHD group and non-diabetic CHD group. (C) Detection of platelet-leukocyte (CD45+ CD41a+) adhesion by flow cytometry of diabetic CHD group (n=121) and non-diabetic CHD group (n=102). Values are expressed as mean±SD. Analyses were done by t-test for independent samples. *P<0.05; **P<0.01; ***P<0.001 vs. diabetic CHD group. Definition of abbreviations: PLA: platelet-leukocyte aggregate levels; PMA: platelet monocyte aggregate levels; PLyA: platelet lymphocyte aggregate levels; PNA: platelet neutrophil aggregate levels.