Research Paper Volume 13, Issue 14 pp 19013—19027

Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ

Diabetic rats showed increased CML and decreased GLP-1 levels in plasma. In (A), we showed treatments of Wistar rats. Each rat was given a large doze of STZ or citrate buffer (PH 4.5) to get diabetic rat or control rat. After 8 weeks, cognitive functions of all rats were tested by water maze. “a” in (B) showed increased CML levels, while in (C) showed decreased GLP-1 levels in the plasma of diabetic rats, compared with control rats. Data are represented as mean ± SD; n=4 per group for results of ELISA.

Figure 3. Diabetic rats showed increased CML and decreased GLP-1 levels in plasma. In (A), we showed treatments of Wistar rats. Each rat was given a large doze of STZ or citrate buffer (PH 4.5) to get diabetic rat or control rat. After 8 weeks, cognitive functions of all rats were tested by water maze. “a” in (B) showed increased CML levels, while in (C) showed decreased GLP-1 levels in the plasma of diabetic rats, compared with control rats. Data are represented as mean ± SD; n=4 per group for results of ELISA.