Research Paper Volume 13, Issue 14 pp 19013—19027

Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ

Summary diagram of the relationship among GLP-1, CML and PPAR in cells apoptosis. CML could induce the apoptosis of PC12 cells. GLP-1 could induce the expression of PPAR-γ by binding to GLP-1R. And then, PPAR-γ could attenuate the neuronal apoptosis. Additionally, PPAR-γ may promote the expression of GLP-1R by the interaction between PPAR-γ and the promoter sequence of GLP-1R.

Figure 6. Summary diagram of the relationship among GLP-1, CML and PPAR in cells apoptosis. CML could induce the apoptosis of PC12 cells. GLP-1 could induce the expression of PPAR-γ by binding to GLP-1R. And then, PPAR-γ could attenuate the neuronal apoptosis. Additionally, PPAR-γ may promote the expression of GLP-1R by the interaction between PPAR-γ and the promoter sequence of GLP-1R.