Research Paper Volume 13, Issue 14 pp 19064—19076

Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway

Integrin β1 promoted gastric cancer progression. (A) Top 25 overexpression genes in gastric tumor tissues comparing with normal tissues analyzed by TCGA database. (B) The relative expression of COL1A1 in normal tissues and gastric tumor tissues (stage I, II, III and IV) analyzed by TCGA database. (C) The overall survival of gastric cancer patients with low/high COL1A1 expression analyzed by TCGA database. (D) The relative expression of ITGB1 in normal tissues and gastric tumor tissues (stage I, II, III and IV) analyzed by TCGA database. (E) The overall survival of gastric cancer patients with low/high ITGB1 expression analyzed by TCGA database. (F) Relative expression of type I collagen in chemo-sensitive (CS) and chemo-resistant (CR) tumor tissues from gastric patients, which was examined by immunohistochemistry (n=15). The scale bar is 100 μm. (G) Relative expression of ITGB1 in chemo-sensitive (CS) and chemo-resistant (CR) tumor tissues from gastric patients, which was examined by immunohistochemistry (n=15). The scale bar is 100 μm. *Indicates P

Figure 1. Integrin β1 promoted gastric cancer progression. (A) Top 25 overexpression genes in gastric tumor tissues comparing with normal tissues analyzed by TCGA database. (B) The relative expression of COL1A1 in normal tissues and gastric tumor tissues (stage I, II, III and IV) analyzed by TCGA database. (C) The overall survival of gastric cancer patients with low/high COL1A1 expression analyzed by TCGA database. (D) The relative expression of ITGB1 in normal tissues and gastric tumor tissues (stage I, II, III and IV) analyzed by TCGA database. (E) The overall survival of gastric cancer patients with low/high ITGB1 expression analyzed by TCGA database. (F) Relative expression of type I collagen in chemo-sensitive (CS) and chemo-resistant (CR) tumor tissues from gastric patients, which was examined by immunohistochemistry (n=15). The scale bar is 100 μm. (G) Relative expression of ITGB1 in chemo-sensitive (CS) and chemo-resistant (CR) tumor tissues from gastric patients, which was examined by immunohistochemistry (n=15). The scale bar is 100 μm. *Indicates P <0.05, n.s indicates no significant difference.