Research Paper Volume 13, Issue 14 pp 19064—19076
Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway
Figure 5. Blockade of β-catenin signals improved outcome of chemotherapy. (A) Tumor volume of SGC-7901 bearing mice treated with PBS, C-IN2, 5-FU and C-IN2 combined with 5-FU. (B) Overall survival of SGC-7901 bearing mice treated with PBS, C-IN2, 5-FU and C-IN2 combined with 5-FU. (C) Tumor volume of ITGB1+ SGC-7901 bearing mice treated with PBS, C-IN2, 5-FU and C-IN2 combined with 5-FU. (D) Overall survival of ITGB1+ SGC-7901 bearing mice treated with PBS, C-IN2, 5-FU and C-IN2 combined with 5-FU. (E) Schematic diagram of ITGB1 induced tumor progression in gastric cancer. * Indicates P <0.05, ** indicates P <0.01, n.s indicates no significant difference.