Research Paper Volume 13, Issue 14 pp 18131—18149

Grape skin extract modulates neuronal stem cell proliferation and improves spatial learning in senescence-accelerated prone 8 mice

Effect of Grape skin extract (GSE) on (A) the cell viability and (B) amyloid-β42 (Aβ42)-induced changes in SH-SY5Y cells. And effect of malvidin-3,5-diglucoside (M3,5dG) and delphinidin-3-glucoside (D3G) on (C) the cell viability and amyloid-β42 (Aβ42)-induced cytotoxicity in SH-SY5Y cells. The cells were treated with or without 20 μg/mL GSE, 12.56 μM M3,5dG, 10.6 D3G, and 15 μM Aβ42 for 72 hr. Each bar represents the mean ± SEM (n = 5 independent experiments). ** P 42-treated cells.

Figure 2. Effect of Grape skin extract (GSE) on (A) the cell viability and (B) amyloid-β42 (Aβ42)-induced changes in SH-SY5Y cells. And effect of malvidin-3,5-diglucoside (M3,5dG) and delphinidin-3-glucoside (D3G) on (C) the cell viability and amyloid-β42 (Aβ42)-induced cytotoxicity in SH-SY5Y cells. The cells were treated with or without 20 μg/mL GSE, 12.56 μM M3,5dG, 10.6 D3G, and 15 μM Aβ42 for 72 hr. Each bar represents the mean ± SEM (n = 5 independent experiments). ** P < 0.01 vs control cells, ## P < 0.01 vs Aβ42-treated cells.