Figure 5. Effect of Grape skin extract (GSE) administration on spatial learning and memory as evaluated by escape latency of senescence-accelerated resistant mouse 1 (SAMR1) mice, senescence-accelerated prone mouse 8 (SAMP8) mice, and SAMP8 50 mg/kg GSE-treated group by Morris water maze test. (A) Effect of GSE on the time spent in the target quadrant. (B) Effect of GSE on numbers of crossings of platform by SAMR1 water-administered and SAMP8 GSE-treated or water-treated mice. (C) * P < 0.05, ** P < 0.01 Compared with SAMP8+Water group by one-way ANOVA analysis.