Figure 6. Effect of oral administration of Grape skin extract (GSE) on dorsal dentate gyrus (DG). SAMP8 mice were gavaged orally with GSE (50 mg/kg) for 30 days. (A) Photomicrograph shows adult mouse brain in coronal sections containing the DG processed for immunohistochemical detection of proliferating BrdU+ cells (green) and DCX (red). (B, C) Graphs represent the number of BrdU+ and DCX+ cells, respectively in the different treatment groups. (D) Graph represents the number of BrdU+ cells that co-express DCX in the different treatment groups. Each bar represents the mean ± SEM. * P < 0.05 compared with SAMP8+Water group by one-way ANOVA.