Research Paper Volume 13, Issue 15 pp 19678—19695

Identification of inflammation-related DNA methylation biomarkers in periodontitis patients based on weighted co-expression analysis

Validation of the diagnostic model. (A) The classification of samples in the GSE53849 data set by the diagnostic model. (B) The ROC curve of the diagnostic model in the GSE53849 data set. (C) Heat map of the expression distribution of 5 immune genes annotated by 5 CpG in disease and normal samples. (D) The classification of samples in the combined validation data sets (GSE59939 and GSE53849) by the diagnostic model. (E) The ROC curve of the diagnostic model in the combined validation data sets (GSE59939 and GSE53849) data set. (F) The classification result of the sample by the diagnostic model constructed by immune genes. (G) ROC curve of the diagnostic model constructed by immune genes.

Figure 6. Validation of the diagnostic model. (A) The classification of samples in the GSE53849 data set by the diagnostic model. (B) The ROC curve of the diagnostic model in the GSE53849 data set. (C) Heat map of the expression distribution of 5 immune genes annotated by 5 CpG in disease and normal samples. (D) The classification of samples in the combined validation data sets (GSE59939 and GSE53849) by the diagnostic model. (E) The ROC curve of the diagnostic model in the combined validation data sets (GSE59939 and GSE53849) data set. (F) The classification result of the sample by the diagnostic model constructed by immune genes. (G) ROC curve of the diagnostic model constructed by immune genes.