Research Paper Volume 13, Issue 15 pp 19760—19775

miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis

Graphical abstract. Il-4/13 induces M2-TAMs, and miR-221-3p produced by M2-TAM exosomes targets and dampens SOCS3, thus phosphorylating JAK2/STAT3, stimulating proliferation, migration and invasion of OS cells, and hampering cell apoptosis. The arrow indicates the activation effect, and the T symbol represents the inhibitory effect.

Figure 9. Graphical abstract. Il-4/13 induces M2-TAMs, and miR-221-3p produced by M2-TAM exosomes targets and dampens SOCS3, thus phosphorylating JAK2/STAT3, stimulating proliferation, migration and invasion of OS cells, and hampering cell apoptosis. The arrow indicates the activation effect, and the T symbol represents the inhibitory effect.