Research Paper Volume 13, Issue 15 pp 19822—19834

Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma

CircZNF609 contributes to melanoma cell survival by miR-138-5p/SIRT7 axis. (A–D) The A375 and SK-MEL-28 cells were treated with control shRNA or circZNF609 shRNA, co-treated with circZNF609 shRNA and miR-138-5p inhibitor or pcDNA3.1-SIRT7. (A and B) The cell viability was measured by MTT assays in the cells. (C and D) The cell apoptosis was analyzed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: *P **P

Figure 6. CircZNF609 contributes to melanoma cell survival by miR-138-5p/SIRT7 axis. (AD) The A375 and SK-MEL-28 cells were treated with control shRNA or circZNF609 shRNA, co-treated with circZNF609 shRNA and miR-138-5p inhibitor or pcDNA3.1-SIRT7. (A and B) The cell viability was measured by MTT assays in the cells. (C and D) The cell apoptosis was analyzed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: *P < 0.05, **P < 0.01.