Research Paper Volume 13, Issue 15 pp 19835—19866

Bisphosphonates and breast cancer survival: a meta-analysis and trial sequential analysis of 81508 participants from 23 prospective epidemiological studies

Summarized results of bisphosphonates and breast cancer survival by recurrence site. (A) Conventional subgroup meta-analysis by recurrence site; (B) Trial sequential analysis for subgroups of bone metastases; (C) Non-skeletal distant metastases; (D) Local-regional relapses and (E) contralateral breast cancer.

Figure 4. Summarized results of bisphosphonates and breast cancer survival by recurrence site. (A) Conventional subgroup meta-analysis by recurrence site; (B) Trial sequential analysis for subgroups of bone metastases; (C) Non-skeletal distant metastases; (D) Local-regional relapses and (E) contralateral breast cancer.