Research Paper Volume 13, Issue 15 pp 19165—19185

Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging

Concentration-dependent contractions to PGF2α (A, B) and phenylephrine (C, D) in isolated aortic rings derived from young and aged eAPP−/− mice and their respective wild-type (WT) littermates. Results are shown as mean ± SEM (n=9 per group for young WT littermates and eAPP−/− mice and n=8 per group for aged WT littermates and eAPP−/− mice) and contractions are expressed as percentage of response to a second KCl (80 mmol/L). No significant differences were detected between WT littermates and eAPP−/− mice at same age (ANOVA with Bonferroni's correction).

Figure 2. Concentration-dependent contractions to PGF (A, B) and phenylephrine (C, D) in isolated aortic rings derived from young and aged eAPP−/− mice and their respective wild-type (WT) littermates. Results are shown as mean ± SEM (n=9 per group for young WT littermates and eAPP−/− mice and n=8 per group for aged WT littermates and eAPP−/− mice) and contractions are expressed as percentage of response to a second KCl (80 mmol/L). No significant differences were detected between WT littermates and eAPP−/− mice at same age (ANOVA with Bonferroni's correction).