Figure 3. Endothelium-dependent relaxations to ACh in isolated aorta from young (A; n=9 per group) and aged (B; n=8 per group) wild-type (WT) littermates and eAPP−/− mice aortas. Effects of indomethacin (Indo; 10-5 mol/L) on responses to ACh in young (C; n=9 per group) and aged (D; n=7 per group) WT littermates and eAPP−/− mice aortas. Results are shown as mean ± SEM and expressed as percent relaxation from submaximal contractions induced by PGF2α. * P>0.05 versus wild-type littermates (ANOVA with Bonferroni's correction).