Research Paper Volume 13, Issue 15 pp 19165—19185

Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging

Effects of aging on ex-vivo secretion of prostaglandins from wild-type (WT) littermates and eAPP−/− mice aortas. The supernatants were collected and analyzed for TXB2 (A; n=11 per group for young mice and n=9 per group for aged mice), PGE2 (B; n=11 per group for young mice and n=9 per group for aged mice); PGF2α (C; n=8 per group for young mice and n=8 per group for aged mice); and 6-keto PGF1α (D; n=11 per group for young mice and n=7-9 per group for aged mice). All results were normalized against tissue protein levels and are representing box plots with whiskers showing the median, 25th to 75th percentiles, and min-max range. * P

Figure 4. Effects of aging on ex-vivo secretion of prostaglandins from wild-type (WT) littermates and eAPP−/− mice aortas. The supernatants were collected and analyzed for TXB2 (A; n=11 per group for young mice and n=9 per group for aged mice), PGE2 (B; n=11 per group for young mice and n=9 per group for aged mice); PGF (C; n=8 per group for young mice and n=8 per group for aged mice); and 6-keto PGF (D; n=11 per group for young mice and n=7-9 per group for aged mice). All results were normalized against tissue protein levels and are representing box plots with whiskers showing the median, 25th to 75th percentiles, and min-max range. * P<0.05 versus young mice of same strain (two-way ANOVA followed by Tukey’s HSD test).