Research Paper Volume 13, Issue 16 pp 20359—20371

LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells

lncRNA GACAT1 directly targeted miR-149 to regulate its expression. (A) miRanda website predicted that lncRNA GACAT1 and miR-149 can be directly targeted to bind; (B) Transfection of lncRNA GACAT1-WT and miR-149 mimics inhibited luciferase activity in OSCC cells; (C) Effects of si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors on lncRNA GACAT1 expression in OSCC cells respectively or in combination; (D) Effects of si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors on miR-149 expression in OSCC cells respectively or in combination. **p

Figure 2. lncRNA GACAT1 directly targeted miR-149 to regulate its expression. (A) miRanda website predicted that lncRNA GACAT1 and miR-149 can be directly targeted to bind; (B) Transfection of lncRNA GACAT1-WT and miR-149 mimics inhibited luciferase activity in OSCC cells; (C) Effects of si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors on lncRNA GACAT1 expression in OSCC cells respectively or in combination; (D) Effects of si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors on miR-149 expression in OSCC cells respectively or in combination. **p < 0.01.