Research Paper Volume 13, Issue 17 pp 21216—21231

Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment

WISP2 mRNA level is lower compared with normal tissues, and low expression of WISP2 is associated with poor prognosis. (A) TIMER database was used to evaluate the WISP2 RNA-seq data in human cancers, and the expression of WISP2 was lower in most human cancers, including HCC. (B) The expression of WISP2 was lower in tumour tissues of HCC than normal tissues in GEPIA2 database. (C) The role of WISP2 on prognosis varied in 33 human cancers, and in HCC, WISP2 had a protective role from GEPIA2 database. (D) The protective role of WISP2 in HCC was confirmed using the Kaplan–Meier plotter, and low expression of WISP2 is associated with poor prognosis.

Figure 1. WISP2 mRNA level is lower compared with normal tissues, and low expression of WISP2 is associated with poor prognosis. (A) TIMER database was used to evaluate the WISP2 RNA-seq data in human cancers, and the expression of WISP2 was lower in most human cancers, including HCC. (B) The expression of WISP2 was lower in tumour tissues of HCC than normal tissues in GEPIA2 database. (C) The role of WISP2 on prognosis varied in 33 human cancers, and in HCC, WISP2 had a protective role from GEPIA2 database. (D) The protective role of WISP2 in HCC was confirmed using the Kaplan–Meier plotter, and low expression of WISP2 is associated with poor prognosis.