Research Paper Volume 13, Issue 16 pp 20395—20417

ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma

Different expression of ADAM15 in HCC tissues and corresponding noncancerous tissues. (A) ADAM15 expression in pan-cancer. (B) ADAM15 expression was up-regulated in HCC tissues compared with paired noncancerous tissues by the TCGA database. (C, D) The level of ADAM15 expression was higher in HCC tissues than that in matched noncancerous tissues by the GEO database (GSE76427 and GSE54236). (E) ADAM15 expression in HCC samples and paired noncancerous samples was confirmed by western blot, and higher ADAM15 expression was in HCC tissues compared with matched noncancerous tissues. (F) ADAM15 expression in HCC samples and paired noncancerous samples was verified by RT-qPCR, and higher ADAM15 expression was in HCC tissues compared with matched noncancerous tissues. (G) ADAM15 expression in HCC samples and paired noncancerous samples was confirmed by IHC, and the value of MOD was higher in HCC tissues compared with matched noncancerous tissues. Magnification, ×200. Scale bar: 50 μm (H, I, J) Validation of diagnostic value of ADAM15 overexpression in HCC based on the TCGA and GEO databases.

Figure 1. Different expression of ADAM15 in HCC tissues and corresponding noncancerous tissues. (A) ADAM15 expression in pan-cancer. (B) ADAM15 expression was up-regulated in HCC tissues compared with paired noncancerous tissues by the TCGA database. (C, D) The level of ADAM15 expression was higher in HCC tissues than that in matched noncancerous tissues by the GEO database (GSE76427 and GSE54236). (E) ADAM15 expression in HCC samples and paired noncancerous samples was confirmed by western blot, and higher ADAM15 expression was in HCC tissues compared with matched noncancerous tissues. (F) ADAM15 expression in HCC samples and paired noncancerous samples was verified by RT-qPCR, and higher ADAM15 expression was in HCC tissues compared with matched noncancerous tissues. (G) ADAM15 expression in HCC samples and paired noncancerous samples was confirmed by IHC, and the value of MOD was higher in HCC tissues compared with matched noncancerous tissues. Magnification, ×200. Scale bar: 50 μm (H, I, J) Validation of diagnostic value of ADAM15 overexpression in HCC based on the TCGA and GEO databases.