Research Paper Volume 13, Issue 16 pp 20395—20417

ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma

Impacts of ADAM15 on the expression of apoptosis-related proteins and EMT-related proteins. (A) Functional enrichment analyses indicated that overexpression of ADAM15 was associated with apoptosis. (B) Functional enrichment analyses indicated that overexpression of ADAM15 was related to focal adhesion. (C) Flow cytometry analysis indicated that the siRNA-transfected in SMMC-7721 cells significantly induced apoptosis. (D) Flow cytometry analysis indicated that the overexpression of ADAM15 in HepG2 cells significantly suppressed apoptosis. (E) Comparison of apoptosis-related protein expression between the control group and siRNA3 group in SMMC-7721 cells. (F) Comparison of apoptosis-related protein expression between the control group and overexpression of ADAM15 group in HepG2 cell. (G) Comparison of EMT-related protein expression between the control group and siRNA3 group in SMMC-7721 cells. (H) Comparison of EMT-related protein expression between the control group and overexpression of ADAM15 group in HepG2 cells.

Figure 8. Impacts of ADAM15 on the expression of apoptosis-related proteins and EMT-related proteins. (A) Functional enrichment analyses indicated that overexpression of ADAM15 was associated with apoptosis. (B) Functional enrichment analyses indicated that overexpression of ADAM15 was related to focal adhesion. (C) Flow cytometry analysis indicated that the siRNA-transfected in SMMC-7721 cells significantly induced apoptosis. (D) Flow cytometry analysis indicated that the overexpression of ADAM15 in HepG2 cells significantly suppressed apoptosis. (E) Comparison of apoptosis-related protein expression between the control group and siRNA3 group in SMMC-7721 cells. (F) Comparison of apoptosis-related protein expression between the control group and overexpression of ADAM15 group in HepG2 cell. (G) Comparison of EMT-related protein expression between the control group and siRNA3 group in SMMC-7721 cells. (H) Comparison of EMT-related protein expression between the control group and overexpression of ADAM15 group in HepG2 cells.