Research Paper Volume 13, Issue 16 pp 20438—20467

Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer

Ceruloplasmin transcript levels in diverse cancer types. (A) Differential ceruloplasmin mRNA expression between tumor tissues and normal tissues in the TIMER database. (B) Significant upregulation (red) and downregulation (blue) of ceruloplasmin mRNA in cancer tissues compared with normal tissues. (C) Box plots demonstrating ceruloplasmin expression in the Turashvili breast, Finak breast, Sorlie breast and TCGA breast datasets. (D, E) The mRNA levels of ceruloplasmin were lower in BRCA than in normal tissues in the GEPIA2 and UALCAN databases. (F) Ceruloplasmin expression levels in BRCA samples obtained from TCGA. (G) Ceruloplasmin expression in 112 matched BRCA and normal breast tissues in the TCGA database was examined. *

Figure 1. Ceruloplasmin transcript levels in diverse cancer types. (A) Differential ceruloplasmin mRNA expression between tumor tissues and normal tissues in the TIMER database. (B) Significant upregulation (red) and downregulation (blue) of ceruloplasmin mRNA in cancer tissues compared with normal tissues. (C) Box plots demonstrating ceruloplasmin expression in the Turashvili breast, Finak breast, Sorlie breast and TCGA breast datasets. (D, E) The mRNA levels of ceruloplasmin were lower in BRCA than in normal tissues in the GEPIA2 and UALCAN databases. (F) Ceruloplasmin expression levels in BRCA samples obtained from TCGA. (G) Ceruloplasmin expression in 112 matched BRCA and normal breast tissues in the TCGA database was examined. *<0.05, **<0.01, ***<0.001.