Research Paper Volume 13, Issue 16 pp 20495—20510

Anti-apoptotic and pro-survival effect of exercise training on early aged hypertensive rat cerebral cortex

The endonuclease G (EndoG) and apoptosis-inducing factor (AIF) caspase-independent apoptotic pathway in a normotensive Wistar Kyoto (WKY) group, a spontaneously early aged hypertensive (SHR) group and a hypertension with 12 weeks exercise training (SHR-EX) group. (A) The 3 representative protein levels of AIF and EndoG extracted from the cerebral cortex of excised brain in WKY, SHR, and SHR-EX groups were measured by Wester blotting analysis. The α-tubulin was used as an internal control. (B) Bars represent the relative fold changes of protein quantification relative to the control group in EndoG and AIF proteins on α-tubulin and mean values ± SD (n=6 in each group). *: pppp

Figure 2. The endonuclease G (EndoG) and apoptosis-inducing factor (AIF) caspase-independent apoptotic pathway in a normotensive Wistar Kyoto (WKY) group, a spontaneously early aged hypertensive (SHR) group and a hypertension with 12 weeks exercise training (SHR-EX) group. (A) The 3 representative protein levels of AIF and EndoG extracted from the cerebral cortex of excised brain in WKY, SHR, and SHR-EX groups were measured by Wester blotting analysis. The α-tubulin was used as an internal control. (B) Bars represent the relative fold changes of protein quantification relative to the control group in EndoG and AIF proteins on α-tubulin and mean values ± SD (n=6 in each group). *: p<0.05, **: p<0.01 in comparison between SHR group and WKY rat group; #: p<0.05, ##: p<0.01 in comparison between SHR-EX group and SHR group.