Figure 6. CRC with IVE had fewer CD3+ and CD8+ TILs. (A) representative images of CD3+ and CD8+ TILs in different regions of tumors with or without IVE. Stromal, tumoral, and boundary regions are indicated by red, black and blue rectangles, respectively. (B) tumor with IVE had fewer stromal CD3+ TILs compared with non-IVE. (C) tumors with IVE had fewer stromal and tumoral CD8+ TILs compared with non-IVE. (D) tumors with IVE had fewer boundary CD3+ TILs but similar CD3+ TILs. (NS, P > 0.05; *, P < 0.05; **, P < 0.01; ***, P < 0.001).