Research Paper Volume 13, Issue 16 pp 20651—20660

NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway

Knockdown of NLRC5 increased the production of inflammatory cytokines in IL-1β-stimulated human OA chondrocytes. After transfection with si-NLRC5/si-NC and the following incubation with IL-1β, (A–D) the production of TNF-α, IL-6, MMP-3 and MMP-13 were detected using ELISA. *p

Figure 5. Knockdown of NLRC5 increased the production of inflammatory cytokines in IL-1β-stimulated human OA chondrocytes. After transfection with si-NLRC5/si-NC and the following incubation with IL-1β, (AD) the production of TNF-α, IL-6, MMP-3 and MMP-13 were detected using ELISA. *p < 0.05.