Research Paper Volume 13, Issue 16 pp 20651—20660

NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway

NLRC5 inhibited IL-1β-induced NF-κB activation in chondrocytes. After transfection with pcDNA3.1-NLRC5 or pcDNA3.1 vector, the chondrocytes were stimulated by IL-1β (10 ng/ml) for 24 h. (A–C) The expression levels of p-p65, p65, IĸBα were determined using western blot analysis. *p

Figure 6. NLRC5 inhibited IL-1β-induced NF-κB activation in chondrocytes. After transfection with pcDNA3.1-NLRC5 or pcDNA3.1 vector, the chondrocytes were stimulated by IL-1β (10 ng/ml) for 24 h. (AC) The expression levels of p-p65, p65, IĸBα were determined using western blot analysis. *p < 0.05.