Research Paper Volume 13, Issue 17 pp 21345—21363

Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis

CircARF3 was down-regulated in plasma and CSF of SAH patients. (A–D) RT-PCR was used to detect the changes of circARF3 (A, B) and miR-31-5p (C, D) in plasma and cerebrospinal fluid (CSF) of patients with different grades of SAH. (E, F) The correlation between circARF3 and miR-31-5p in plasma and CSF of SAH patients was analyzed by Pearson linear regression. (G–J) Levels of IL-1β and TNF-α in plasma and CSF samples of SAH patients were determined by ELISA. * * * indicated that P

Figure 1. CircARF3 was down-regulated in plasma and CSF of SAH patients. (AD) RT-PCR was used to detect the changes of circARF3 (A, B) and miR-31-5p (C, D) in plasma and cerebrospinal fluid (CSF) of patients with different grades of SAH. (E, F) The correlation between circARF3 and miR-31-5p in plasma and CSF of SAH patients was analyzed by Pearson linear regression. (GJ) Levels of IL-1β and TNF-α in plasma and CSF samples of SAH patients were determined by ELISA. * * * indicated that P < 0.001. Each experiment was repeated for 3 times.