Research Paper Volume 13, Issue 16 pp 20836—20852

Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer

Correlation of HPSE expression with immune infiltration level in BLCA and BRCA. In BLCA, HPSE expression has no correlation with infiltrating levels of B cells, medium correlation with infiltrating levels of CD8+ T cells, weak correlation with infiltrating levels of CD4+ T cells and macrophages, and a strong correlation with infiltrating levels of neutrophils and dendritic cells. In BRCA, HPSE expression has medium correlation with infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, and macrophages, and a strong correlation with infiltrating levels of neutrophils and dendritic cells.

Figure 3. Correlation of HPSE expression with immune infiltration level in BLCA and BRCA. In BLCA, HPSE expression has no correlation with infiltrating levels of B cells, medium correlation with infiltrating levels of CD8+ T cells, weak correlation with infiltrating levels of CD4+ T cells and macrophages, and a strong correlation with infiltrating levels of neutrophils and dendritic cells. In BRCA, HPSE expression has medium correlation with infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, and macrophages, and a strong correlation with infiltrating levels of neutrophils and dendritic cells.