Research Paper Volume 13, Issue 17 pp 21526—21546

Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction

Midlife liver gene expression correlations with lifespan are predictive of aging regulators. (A) GO analysis of target genes with expression levels that are most positively correlated with the lifespan. (B) GO analysis of target genes with expression levels that are most negatively correlated with the lifespan. (C) Gene network modules depicting the pathways and genes that are most positively correlated with the lifespan. (D) Gene network modules showing the pathways and genes that are most negatively correlated with the lifespan. (E) mRNA expression of genes that are significantly positively correlated with the lifespan. (F) mRNA expression of genes that are significantly negatively correlated with the lifespan.

Figure 6. Midlife liver gene expression correlations with lifespan are predictive of aging regulators. (A) GO analysis of target genes with expression levels that are most positively correlated with the lifespan. (B) GO analysis of target genes with expression levels that are most negatively correlated with the lifespan. (C) Gene network modules depicting the pathways and genes that are most positively correlated with the lifespan. (D) Gene network modules showing the pathways and genes that are most negatively correlated with the lifespan. (E) mRNA expression of genes that are significantly positively correlated with the lifespan. (F) mRNA expression of genes that are significantly negatively correlated with the lifespan.