Research Paper Advance Articles

Low expression of KIF20A suppresses cell proliferation, promotes chemosensitivity and is associated with better prognosis in HCC

Effects of KIF20A knockdown on the chemo-sensitivity of HCC cells. (A) Cell viability of si-NC or si-KIF20A-transfected HepG2 cells after treatment with different concentrations of cisplatin. (B) IC50 values of cisplatin in HepG2 cells transfected with si-NC or si-KIF20A. (C) Cell viability of si-NC or si-KIF20A-transfected SK-Hep1 cells after treatment with different concentrations of cisplatin. (D) IC50 values of cisplatin in SK-Hep1 cells transfected with si-NC or si-KIF20A. (E) Cell viability of si-NC or si-KIF20A-transfected HepG2 cells after treatment with different concentrations of sorafenib. (F) IC50 values of sorafenib in HepG2 cells transfected with si-NC or si-KIF20A. (G) Cell viability of si-NC or si-KIF20A-transfected SK-Hep1 cells after treatment with different concentrations of sorafenib. (H) IC50 values of sorafenib in SK-Hep1 cells transfected with si-NC or si-KIF20A. N = 3; *P

Figure 8. Effects of KIF20A knockdown on the chemo-sensitivity of HCC cells. (A) Cell viability of si-NC or si-KIF20A-transfected HepG2 cells after treatment with different concentrations of cisplatin. (B) IC50 values of cisplatin in HepG2 cells transfected with si-NC or si-KIF20A. (C) Cell viability of si-NC or si-KIF20A-transfected SK-Hep1 cells after treatment with different concentrations of cisplatin. (D) IC50 values of cisplatin in SK-Hep1 cells transfected with si-NC or si-KIF20A. (E) Cell viability of si-NC or si-KIF20A-transfected HepG2 cells after treatment with different concentrations of sorafenib. (F) IC50 values of sorafenib in HepG2 cells transfected with si-NC or si-KIF20A. (G) Cell viability of si-NC or si-KIF20A-transfected SK-Hep1 cells after treatment with different concentrations of sorafenib. (H) IC50 values of sorafenib in SK-Hep1 cells transfected with si-NC or si-KIF20A. N = 3; *P<0.05, **P<0.01 and ***P<0.001.