Research Paper Volume 13, Issue 17 pp 21029—21039

Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH

Concentration profiles of bone resorption (CTX) and bone formation (P1NP) markers over time in offspring from long-lived families (n = 14) and controls (n = 12) following a challenge with 0.1 mg rhTSH. (A) Mean circulating CTX at 24-hour intervals following rhTSH administration. (B) Mean circulating P1NP at 24-hour intervals following rhTSH administration. rhTSH: recombinant human thyroid stimulating hormone, CTX: collagen type 1 C-terminal cross-linked telopeptide (CTX), P1NP: N-terminal propeptide of type 1 collagen. Error bars: standard error of the mean.

Figure 3. Concentration profiles of bone resorption (CTX) and bone formation (P1NP) markers over time in offspring from long-lived families (n = 14) and controls (n = 12) following a challenge with 0.1 mg rhTSH. (A) Mean circulating CTX at 24-hour intervals following rhTSH administration. (B) Mean circulating P1NP at 24-hour intervals following rhTSH administration. rhTSH: recombinant human thyroid stimulating hormone, CTX: collagen type 1 C-terminal cross-linked telopeptide (CTX), P1NP: N-terminal propeptide of type 1 collagen. Error bars: standard error of the mean.