Research Paper Volume 13, Issue 17 pp 21743—21757

lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1

HCG11 expression is decreased in OS and closely related to clinical factors. (A) HCG11 expression in OS tissues and ANTs was analyzed by qRT-PCR. (B) The ratio of relative HCG11 expression in OS tissues versus ANTs shown on the logarithmic scale. (C) HCG11 expression in OS cell lines (MG63, HOS, Saos-2, U2OS and 143B) and human osteoblast cell line (hFOB1.19) was analyzed by qRT-PCR. (D) HCG11 level in tumors ≥ 5cm and E) Overall survival of OS patients was analyzed by the Kaplan-Meier method. **P ***P

Figure 1. HCG11 expression is decreased in OS and closely related to clinical factors. (A) HCG11 expression in OS tissues and ANTs was analyzed by qRT-PCR. (B) The ratio of relative HCG11 expression in OS tissues versus ANTs shown on the logarithmic scale. (C) HCG11 expression in OS cell lines (MG63, HOS, Saos-2, U2OS and 143B) and human osteoblast cell line (hFOB1.19) was analyzed by qRT-PCR. (D) HCG11 level in tumors ≥ 5cm and < 5cm was compared. (E) Overall survival of OS patients was analyzed by the Kaplan-Meier method. **P < 0.01, ***P < 0.001.