Research Paper Volume 13, Issue 17 pp 21758—21777

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

Differentially expressed genes analyzed in the GSE20347, GSE17351 and private datasets. (A) Flow chart of the data analysis in this study. (B) Venn diagrams of the DEGs from the GSE20347, GSE17351 and private datasets. (C) Heatmap of 64 DEGs from the private dataset. (D) Visual PPI network of 64 DEGs from Cytoscape. Upregulated genes are marked in red; downregulated genes are marked in blue. (E) Fourteen hub genes screened by a degree > 4.

Figure 1. Differentially expressed genes analyzed in the GSE20347, GSE17351 and private datasets. (A) Flow chart of the data analysis in this study. (B) Venn diagrams of the DEGs from the GSE20347, GSE17351 and private datasets. (C) Heatmap of 64 DEGs from the private dataset. (D) Visual PPI network of 64 DEGs from Cytoscape. Upregulated genes are marked in red; downregulated genes are marked in blue. (E) Fourteen hub genes screened by a degree > 4.