Research Paper Volume 13, Issue 18 pp 22276—22285

Improvement of cardiac function by mesenchymal stem cells derived extracellular vesicles through targeting miR-497/Smad7 axis

Overexpression of miR-497 reversed the promotion of cell migration, invasion, and proliferation caused by EVs. (A) Influence of EVs and miR-497 mimics on cell invasion; (B) The influence of EVs and miR-497 mimics on cell invasion was analyzed; (C) Influence of EVs and miR-497 mimics on cell migration; (D) The influence of EVs and miR-497 mimics on cell migration was analyzed; (E) I The influence of EVs and miR-497 mimics on cell proliferation was analyzed. + indicated P

Figure 2. Overexpression of miR-497 reversed the promotion of cell migration, invasion, and proliferation caused by EVs. (A) Influence of EVs and miR-497 mimics on cell invasion; (B) The influence of EVs and miR-497 mimics on cell invasion was analyzed; (C) Influence of EVs and miR-497 mimics on cell migration; (D) The influence of EVs and miR-497 mimics on cell migration was analyzed; (E) I The influence of EVs and miR-497 mimics on cell proliferation was analyzed. + indicated P<0.05 compared with the group control. * indicated P<0.05 compared with the group hypoxia. # indicated P<0.05 compared with group hypoxia+EVs.