Research Paper Volume 13, Issue 18 pp 22286—22297

ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

Expressions of ASXL1 and FSCN1 was positively correlated. Reproduced from the GDSC dataset, shown were volcano plots of drug sensitivity of gain of cytoband encompassing ASXL1 in pan-cancer cell lines from (A) GDSC1 and GDSC2 repositories and (B) retrieved P values for Doxorubicin, Etoposide and Cisplatin; (C) Reproduced from ChIP-Atlas, shown was heatmap ranked by binding score of ASXL1 from high to low in different model cells (human 293 cells), each row representing one gene; (D) Reproduced from the TCGA adrenocortical carcinoma (ACC) dataset, shown was expression correlation between ASXL1 and FSCN1 in ACC samples; (E) Reproduced from the GTEx dataset, shown was expression correlation between ASXL1 and FSCN1 in normal adrenal samples; (F) Representative IHC image of ASXL1 and FSCN1 staining in ACC samples with numbers indicating IHC score; (G) Reproduced from The Cancer Therapeutics Response Portal, shown were box plots of correlation coefficients between area under control and gene expression in cancer cells.

Figure 2. Expressions of ASXL1 and FSCN1 was positively correlated. Reproduced from the GDSC dataset, shown were volcano plots of drug sensitivity of gain of cytoband encompassing ASXL1 in pan-cancer cell lines from (A) GDSC1 and GDSC2 repositories and (B) retrieved P values for Doxorubicin, Etoposide and Cisplatin; (C) Reproduced from ChIP-Atlas, shown was heatmap ranked by binding score of ASXL1 from high to low in different model cells (human 293 cells), each row representing one gene; (D) Reproduced from the TCGA adrenocortical carcinoma (ACC) dataset, shown was expression correlation between ASXL1 and FSCN1 in ACC samples; (E) Reproduced from the GTEx dataset, shown was expression correlation between ASXL1 and FSCN1 in normal adrenal samples; (F) Representative IHC image of ASXL1 and FSCN1 staining in ACC samples with numbers indicating IHC score; (G) Reproduced from The Cancer Therapeutics Response Portal, shown were box plots of correlation coefficients between area under control and gene expression in cancer cells.