Research Paper Volume 13, Issue 18 pp 22286—22297

ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

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Figure 2. Expressions of ASXL1 and FSCN1 was positively correlated. Reproduced from the GDSC dataset, shown were volcano plots of drug sensitivity of gain of cytoband encompassing ASXL1 in pan-cancer cell lines from (A) GDSC1 and GDSC2 repositories and (B) retrieved P values for Doxorubicin, Etoposide and Cisplatin; (C) Reproduced from ChIP-Atlas, shown was heatmap ranked by binding score of ASXL1 from high to low in different model cells (human 293 cells), each row representing one gene; (D) Reproduced from the TCGA adrenocortical carcinoma (ACC) dataset, shown was expression correlation between ASXL1 and FSCN1 in ACC samples; (E) Reproduced from the GTEx dataset, shown was expression correlation between ASXL1 and FSCN1 in normal adrenal samples; (F) Representative IHC image of ASXL1 and FSCN1 staining in ACC samples with numbers indicating IHC score; (G) Reproduced from The Cancer Therapeutics Response Portal, shown were box plots of correlation coefficients between area under control and gene expression in cancer cells.